Mechanism of cooperative behaviour in systems of slow and fast molecular motors

Literature Information

Publication Date 2009-05-11
DOI 10.1039/B900968J
Impact Factor 3.676
Authors

Adam G. Larson, Eric C. Landahl, Sarah E. Rice


View Original

Abstract

Two recent theoretical advances have described cargo transport by multiple identical motors and by multiple oppositely directed, but otherwise identical motors [M. J. Muller, S. Klumpp and R. Lipowsky, Proc. Natl. Acad. Sci. U. S. A., 2008, 105(12), 4609–4614; S. Klumpp and R. Lipowsky, Proc. Natl. Acad. Sci. U. S. A., 2005, 102(48), 17284–17289]. Here, we combine a similar theoretical approach with a simple experiment to describe the behaviour of a system comprised of slow and fast molecular motors having the same directionality. We observed the movement of microtubules by mixtures of slow and fast kinesin motors attached to a glass coverslip in a classic sliding filament assay. The motors are identical, except that the slow ones contain five point mutations that collectively reduce their velocity ∼15-fold without compromising maximal ATPase activity. Our results indicate that a small fraction of fast motors are able to accelerate the dissociation of slow motors from microtubules. Because of this, a sharp, highly cooperative transition occurs from slow to fast microtubule movement as the relative number of fast motors in the assay is increased. Microtubules move at half-maximal velocity when only 15% of the motors in the assay are fast. Our model indicates that this behaviour depends primarily on the relative motor velocities and the asymmetry between their forward and backward dissociation forces. It weakly depends on the number of motors and their processivity. We predict that movement of cargoes bound to two types of motors having very different velocities will be dominated by one or the other motor. Therefore, cargoes can potentially undergo abrupt changes in movement in response to regulatory mechanisms acting on only a small fraction of motors.

Related Literature

Solvent selection and Pt decoration towards enhanced photocatalytic CO2 reduction over CsPbBr3 perovskite single crystals

Yi-Xin Chen, Yang-Fan Xu, Xu-Dong Wang, Hong-Yan Chen, Dai-Bin Kuang

2020-02-10 Paper

DOI: 10.1039/C9SE01218D

Low-spin cobalt(ii) redox shuttle by isocyanide coordination

Austin L. Raithel, Tea-Yon Kim, Karl C. Nielsen, Richard J. Staples, Thomas W. Hamann

2020-03-09 Paper

DOI: 10.1039/D0SE00314J

Synthesis of an oxygenated fuel additive from a waste biomass derived aldehyde using a green catalyst: an experimental and DFT study

Komal Kumar, Vikas Khatri, Firdaus Parveen, Hemant K. Kashyap, Sreedevi Upadhyayula

2020-03-23 Paper

DOI: 10.1039/D0SE00100G

Engineering the structural formula of N-doped molybdenum carbide nanowires for the deoxygenation of palmitic acid

Xiaozhen Chen, Xiao Chen, Chuang Li, Changhai Liang

2020-02-25 Paper

DOI: 10.1039/C9SE01307E

Ammonia-etching-assisted nanotailoring of manganese silicate boosts faradaic capacity for high-performance hybrid supercapacitors

Xueying Dong, Yifu Zhang, Qiang Chen, Hanmei Jiang, Qiushi Wang, Changgong Meng, Zongkui Kou

2020-03-03 Paper

DOI: 10.1039/D0SE00042F

Correction: Transgenic PDGF-BB/sericin hydrogel supports for cell proliferation and osteogenic differentiation

Kai Hou, Wenjing Chen, Yuancheng Wang, Riyuan Wang, Chi Tian, Sheng Xu, Yanting Ji, Qianqian Yang, Ping Zhao, Ling Yu, Zhisong Lu, Huijie Zhang, Fushu Li, Han Wang, Baicheng He, David L. Kaplan, Qingyou Xia

2021-05-19 Correction

DOI: 10.1039/D1BM90052H

Back cover

2021-06-04 Cover

DOI: 10.1039/D1BM90057A

Enhanced catalytic performance of CO methanation over VOx assisted Ni/MCF catalyst

Zhiwei Tian, Qing Liu

2020-03-04 Paper

DOI: 10.1039/D0SE00052C

Fuel cell evaluation of anion exchange membranes based on poly(phenylene oxide) with different cationic group placement

Annika Carlson, Björn Eriksson, Joel S. Olsson, Göran Lindbergh, Carina Lagergren, Patric Jannasch, Rakel Wreland Lindström

2020-02-24 Paper

DOI: 10.1039/C9SE01143A

You might also like

Compound Q&A

What industries use 4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine (CAS: 1015845-73-4)?

4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine finds applications in various industri...

1015845-73-44-(4-tert-Butylpheny...
Compound Q&A

What industries use H3TATAB (CAS: 63557-10-8)?

H3TATAB is used in the pharmaceutical industry for the synthesis of certain orga...

63557-10-8H3TATAB
Compound Q&A

What are the main uses of 1-Ethyl-3-fluorobenzene (CAS: 696-39-9)?

1-Ethyl-3-fluorobenzene (CAS: 696-39-9) is primarily used as a precursor in the ...

696-39-91-Ethyl-3-fluorobenz...
Compound Q&A

What are the main uses of 1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid (CAS: 851484-94-1)?

1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid is prim...

851484-94-11-(tert-Butoxycarbon...
Compound Q&A

What are the physical and chemical properties of 1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0)?

1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0) is a colorless or white crystalli...

359880-05-01-Cyclobutyl-4-piper...
Compound Q&A

What is Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0)?

Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0) is a che...

575433-76-0Pyridine-2,6-dicarbo...
Compound Q&A

What is the market or research trend for 2,3-Difluorophenylalanine (CAS: 236754-62-4)?

The market for 2,3-Difluorophenylalanine (CAS: 236754-62-4) is growing with incr...

236754-62-42,3-Difluorophenylal...
Compound Q&A

How is (2-Hydroxy-1-naphthyl)boronic acid (CAS: 898257-48-2) typically synthesized?

(2-Hydroxy-1-naphthyl)boronic acid can be synthesized through the reduction of 2...

898257-48-2(2-Hydroxy-1-naphthy...
1315351-28-0tert-Butyl (5-bromo-...
Compound Q&A

Are there alternatives to 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-glucopyranoside (CAS: 19833-12-6) in synthesis?

While 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-gluc...

19833-12-65,7-Dihydroxy-4-oxo-...

Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.