Design of liposome-based pH sensitive nanoSPINprobes: nano-sized particles with incorporated nitroxides
Literature Information
Publication Date
2009-03-11
DOI
10.1039/B818184E
Impact Factor
4.616
Authors
Andrey A. Bobko, Igor A. Kirilyuk, Julya F. Polienko, Maxim A. Voinov, Elena G. Bagryanskaya, Valery V. Khramtsov
View Original
Abstract
Liposome-based nanoSized Particles with Incorporated Nitroxides, or nanoSPINs, were designed for EPR applications as pH probes in biological systems. Phospholipid membrane of the liposomes with incorporated gramicidin A showed selective permeability to a small analyte, H+, while protecting entrapped sensing nitroxide from biological reductants. An application of the pH-sensitive nanoSPIN in an ischemia model in rat heart homogenate allows for monitoring ischemia-induced acidosis while protecting encapsulated nitroxide against bioreduction.
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Source Journal
Analyst
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
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Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron
CAS Number:
12150-46-8
Molecular Formula:
C34H28FeP2
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