Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(ii) ions

Literature Information

Publication Date 2008-11-20
DOI 10.1039/B816638B
Impact Factor 6.222
Authors

Jianyu Jin, Yongxiang Wang, Hao Wang


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Abstract

We report that the hydrogen-bonding pattern in a molecular beacon can be replaced by metal-dependent pairs of Hg2+ and DNA thymine (T) bases. A molecular beacon based on T–Hg2+–T exhibits a lower background signal and higher thermostability than regular molecular beacons.

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Contents pages

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DOI: 10.1039/AN94267BX031

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Notes from the Reports of Public Analysts

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DOI: 10.1039/AN942670262A

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DOI: 10.1039/AN940650229B

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DOI: 10.1039/AN95277BP031

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DOI: 10.1039/AN943680118B

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DOI: 10.1039/AN942670225B

Food and drugs

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DOI: 10.1039/AN938630896B

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DOI: 10.1039/AN942670113A

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Chemical Communications

Chemical Communications
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ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

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