Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(ii) ions
Literature Information
Jianyu Jin, Yongxiang Wang, Hao Wang
We report that the hydrogen-bonding pattern in a molecular beacon can be replaced by metal-dependent pairs of Hg2+ and DNA thymine (T) bases. A molecular beacon based on T–Hg2+–T exhibits a lower background signal and higher thermostability than regular molecular beacons.
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Joint Meeting with the Food Group of the Society of Chemical Industry
DOI: 10.1039/AN942670078A
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Chemical Communications

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