Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation
Literature Information
Mazen Sleiman, Annabelle Varrot, Jean-Manuel Raimundo, Marc Gingras, Peter G. Goekjian
A new class of sulfurated, semi-rigid, radial and low-valent glycosylated asterisk ligands with potential dual function as ligand and probe has some of the highest inhibition potencies of Con A-induced hemagglutination, by using a cross-linking mechanism of Con A which amplifies the enhancement to near nanomolar concentrations with the α-D-mannose asterisk.
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