A ratiometric fluorescent sensor with a large Stokes shift for imaging zinc ions in living cells
Literature Information
Chun Liu, Hua Jiang
The ratiometric fluorescent sensor FQ1 based on furoquinoline has been designed and synthesized, and not only exhibits a large Stokes shift of 199 nm in a mixture of C2H5OH–H2O (v/v = 8 : 2, 10 mM Tris-HCl, pH = 7.3), but can selectively detect zinc ions in the presence of competing metal ions with a red-shift of 75 nm; moreover, cell stain experiments show that FQ1 can readily reveal a change in intracellular Zn2+.
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