Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

Literature Information

Publication Date 2008-10-24
DOI 10.1039/B814011A
Impact Factor 6.222
Authors

Yuan Fu, Hua Fu, Yufen Zhao


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Abstract

We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2-halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.

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