A modular and organocatalytic approach to γ-butyrolactone autoregulators from Streptomycetes
Literature Information
Petteri Elsner, Hao Jiang, Johanne B. Nielsen, Filippo Pasi, Karl Anker Jørgensen
A general synthesis of optically active γ-butyrolactone autoregulators is developed by a two-step sequence to assemble 2,3-trans-disubstituted butyrolactones in high yields and enantioselectivities; the scope of this reaction was elaborated by setting up a library of alkyl-substituted butyrolactones and the synthesis of the autoregulators IM-2 and VB-D.
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