Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet

Literature Information

Publication Date 2008-09-26
DOI 10.1039/B811159F
Impact Factor 6.222
Authors

Pinpin Sheng, Zunyi Yang, Youngmi Kim, Yanrong Wu, Weihong Tan, Steven A. Benner


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Abstract

A molecular beacon that incorporates components of an artificially expanded genetic information system (AEGIS) in its stem is shown not to be opened by unwanted stem invasion by adventitious standard DNA; this should improve the “darkness” of the beacon in real-world applications.

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