Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet
Literature Information
Pinpin Sheng, Zunyi Yang, Youngmi Kim, Yanrong Wu, Weihong Tan, Steven A. Benner
A molecular beacon that incorporates components of an artificially expanded genetic information system (AEGIS) in its stem is shown not to be opened by unwanted stem invasion by adventitious standard DNA; this should improve the “darkness” of the beacon in real-world applications.
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