1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles

Literature Information

Publication Date 2008-09-08
DOI 10.1039/B809206K
Impact Factor 6.222
Authors

Bas Groenendaal, Eelco Ruijter, Romano V. A. Orru


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Abstract

1-Azadienes are versatile building blocks for the efficient construction of various N-heterocycles. Depending on the substitution pattern and reaction partner, they may participate in a range of different reactions. An overview of recent methods for the generation of 1-azadienes is presented, as well as their application in cycloaddition, electrocyclization, and multicomponent reactions. Considering the broad range of reactivities and resulting heterocyclic scaffold structures, 1-azadienes are very useful reactive intermediates for the development of modular reaction sequences in diversity-oriented synthesis.

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