Lewis base-catalyzed conjugate reduction and reductive aldol reaction of α,β-unsaturated ketones using trichlorosilane

Literature Information

Publication Date 2008-07-17
DOI 10.1039/B807529H
Impact Factor 6.222
Authors

Masaharu Sugiura, Norimasa Sato, Shunsuke Kotani, Makoto Nakajima


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Abstract

Lewis bases such as Ph3PO and HMPA catalyze the 1,4-reduction of α,β-unsaturated ketones with trichlorosilane, and because the 1,2-reduction of aldehydes scarcely proceeded under the conditions, one-pot reductive aldol reactions with aldehydes were successfully achieved; preliminary studies using a chiral Lewis base revealed a high potential for enantioselective catalysis.

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