Activation of organozinc reagents with t-Bu-P4 base for transition metal-free catalytic SN2′ reaction

Literature Information

Publication Date 2008-06-20
DOI 10.1039/B807169A
Impact Factor 6.222
Authors

Koji Kobayashi, Masahiro Ueno, Hiroshi Naka, Yoshinori Kondo


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Abstract

The t-Bu-P4 base was found to be an excellent catalyst for activating organozinc reagents and was used to promote the SN2′ reaction of α,β-unsaturated esters bearing a γ-chloride using various organozinc reagents: these reactions proceeded in high yields with excellent chemo-and regioselectivity.

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