Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)
Literature Information
Stefan K. Weidt, C. Logan Mackay, Pat R. R. Langridge-Smith, Peter J. Sadler
The high mass accuracy of FT-ICR MS combined with 15N-labelling shows that mono- and di- platinated products from the reaction of erythrocytesuperoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.
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