Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

Literature Information

Publication Date 2007-04-05
DOI 10.1039/B701903C
Impact Factor 6.222
Authors

Stefan K. Weidt, C. Logan Mackay, Pat R. R. Langridge-Smith, Peter J. Sadler


View Original

Abstract

The high mass accuracy of FT-ICR MS combined with 15N-labelling shows that mono- and di- platinated products from the reaction of erythrocytesuperoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.

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