Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

Literature Information

Publication Date 2007-02-22
DOI 10.1039/B618923G
Impact Factor 6.222
Authors

Felix Kopp, Stefan Wunderlich, Paul Knochel


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Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.

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