Design of chiral organocatalysts for practical asymmetric synthesis of amino acid derivatives

Literature Information

Publication Date 2006-12-08
DOI 10.1039/B613049F
Impact Factor 6.222
Authors

Keiji Maruoka, Takashi Ooi, Taichi Kano


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Abstract

A series of structurally rigid, chiral quaternary ammonium salts and several chiral sec-amine catalysts derived from commercially available (R)- or (S)-binaphthol have been designed as new C2-symmetric chiral phase-transfer catalysts and chiral bifunctional amino-catalysts. These chiral organocatalysts have been successfully applied to the highly practical asymmetric synthesis of various amino acid derivatives.

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