The depth of molecular recognition: voltage-sensitive blockage of synthetic multifunctional pores with refined architecture

Literature Information

Publication Date 2005-09-05
DOI 10.1039/B509610C
Impact Factor 6.222
Authors

Yoann Baudry, Masamichi Nishihara, Naomi Sakai, Stefan Matile


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Abstract

Voltage-sensitive blockage by ADP, ATP and phytate (IP6) demonstrates that active-site contraction toward the middle of newly synthesized rigid-rod β-barrels provides a general strategy to rationally create and modulate the voltage sensitivity (and to increase the efficiency) of molecular recognition by synthetic multifunctional pores.

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