Novel Pd(ii)-catalysed N,O-bicyclisation as an efficient route to the 6-oxa-2-azabicyclo[3.2.1]octane skeleton
Literature Information
Peter Szolcsányi, Tibor Gracza
1-(Benzyloxycarbonylamino)-hex-5-en-3-ol (5) undergoes a novel Pd(II)/CuCl2-catalysed bicyclisation to furnish the corresponding 6-oxa-2-azabicyclo[3.2.1]octane (6) in good yield.
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![[5-fluoro-2-(morpholine-4-carbonyl)phenyl]boronic acid structure [5-fluoro-2-(morpholine-4-carbonyl)phenyl]boronic acid structure](https://static.chemtradehub.com/structs/121/1217501-26-2-505c.webp)


![2-Methyl-2-propanyl {3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-oxetanyl}carbamate structure 2-Methyl-2-propanyl {3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-oxetanyl}carbamate structure](https://static.chemtradehub.com/structs/127/1279090-25-3-1b84.webp)
