2,2-Dimethyl cyclopentanones by acid catalyzed ring expansion of isopropenylcyclobutanols. A short synthesis of (±)-α-cuparenone and (±)-herbertene

Literature Information

Publication Date 2005-06-23
DOI 10.1039/B505707H
Impact Factor 6.222
Authors

Angela M. Bernard, Angelo Frongia, Francesco Secci, Pier P. Piras


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Abstract

2,2-Dimethyl cyclopentanones are readily prepared by acid catalyzed ring expansion of isopropenylcyclobutanols; the method allows ready access to the family of sesquiterpenes cuparanes and herbertanes, as demonstrated by the synthesis of (±)-α-cuparenone and the direct precursor of (±)-herbertene.

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