Probing the mechanism of Prins cyclisations and application to the synthesis of 4-hydroxytetrahydropyrans
Literature Information
Conor S. Barry, Nick Bushby, John R. Harding, Rachael A. Hughes, Gregory D. Parker, Richard Roe, Christine L. Willis
Trapping intermediates on the Prins cyclisation pathway with carbon-based nucleophiles has given further insight into factors affecting the acid-mediated reactions of homoallylic alcohols with aldehydes, enabling the design of efficient syntheses of 4-hydroxy-2,6-disubstituted tetrahydropyrans.
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![Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron structure Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron structure](https://static.chemtradehub.com/structs/121/12150-46-8-ecd2.webp)