Probing the mechanism of Prins cyclisations and application to the synthesis of 4-hydroxytetrahydropyrans

Literature Information

Publication Date 2005-06-16
DOI 10.1039/B504562B
Impact Factor 6.222
Authors

Conor S. Barry, Nick Bushby, John R. Harding, Rachael A. Hughes, Gregory D. Parker, Richard Roe, Christine L. Willis


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Abstract

Trapping intermediates on the Prins cyclisation pathway with carbon-based nucleophiles has given further insight into factors affecting the acid-mediated reactions of homoallylic alcohols with aldehydes, enabling the design of efficient syntheses of 4-hydroxy-2,6-disubstituted tetrahydropyrans.

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Chemical Communications

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