Oxy-peptide nucleic acid with a pyrrolidine ring that is configurationally optimized for hybridization with DNA
Literature Information
Mizuki Kitamatsu, Masanori Shigeyasu, Tomoyuki Okada, Masahiko Sisido
Four stereoisomers of oxy-peptide nucleic acids containing ether linkages in the main chain and conformationally-restricted pyrrolidine rings (pyrrolidine-based oxy-PNA = POPNA) were newly synthesized and investigated for binding to DNA. cis-L-POPNA with 9 adenine bases formed the most stable hybrid with dT9. The POPNA showed high sequence specificity similar to that of the Nielsen-type PNA and sharper melting behavior in hybridization with DNA than the Nielsen-type PNA.
Recommended Journals
Related Literature
Charge transport in the spatially correlated exponential random energy landscape: effect of the nonpositive correlation function
DOI: 10.1039/D1CP04991G
The effect of intermolecular electronic coupling on the exciton dynamics in perylene red nanoparticles
Chris Rehhagen, Shahnawaz Rafiq, Kyra N. Schwarz, Gregory D. Scholes, Stefan Lochbrunner
DOI: 10.1039/D1CP05375B
Reply to the ‘Comment on “Can bulk nanobubbles be stabilized by electrostatic interaction?”’ by S. Koshoridze and Y. Levin, Phys. Chem. Chem. Phys., 2022, 24, DOI: 10.1039/D1CP04406K
Shuo Wang, Limin Zhou, Yongxiang Gao
DOI: 10.1039/D2CP00852A
Structure, hydrogen bond dynamics and phase transition in a model ionic liquid electrolyte
Peter Stange, Alexander G. Stepanov
DOI: 10.1039/D2CP00452F
Cu2+-Induced self-assembly and amyloid formation of a cyclic d,l-α-peptide: structure and function
Daniel Klose, Michal Richman, Vered Aisha, Meital Abayev, Marina Chemerovski, Katharina Majer, Nino Wili, Gil Goobes, Christian Griesinger, Gunnar Jeschke, Shai Rahimipour
DOI: 10.1039/D1CP05415E
Ultralow work function of the electride Sr3CrN3
Cuicui Wang, Miaoting Xu, Keith T. Butler, Lee A. Burton
DOI: 10.1039/D1CP05623A
Effects of adatom species on the structure, stability, and work function of adatom-α-borophene nanocomposites
Jing He, Bing Zheng, Ying Xie, Yin-yin Qian, Jiao Zhang, Ke Wang, Hai-tao Yu
DOI: 10.1039/D2CP00506A
Multiple-cation wide-bandgap perovskite solar cells grown using cesium formate as the Cs precursor with high efficiency under sunlight and indoor illumination
Qiang Guo, Zongwei Chen, Lei Gao, Chen Duan, Qing Guo, Erjun Zhou
DOI: 10.1039/D2CP02358J
On standardised moments of force distribution in simple liquids
Jonathan Utterson, Radek Erban
DOI: 10.1039/D1CP04056A
Photostability of the deprotonated forms of the UV filters homosalate and octyl salicylate: molecular dissociation versus electron detachment following UV excitation
Natalie G. K. Wong, Conor D. Rankine, Cate S. Anstöter, Caroline E. H. Dessent
DOI: 10.1039/D2CP01612E
You might also like
What precautions should be taken when handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2)?
When handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2), it is importan...
Is 4-(4H-1,2,4-Triazol-4-yl)piperidine (CAS: 690261-92-8) safe?
4-(4H-1,2,4-Triazol-4-yl)piperidine is generally considered safe for use in phar...
How should waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) be handled?
Waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) should be collecte...
What regulatory guidelines apply to 5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3)?
5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3) is subject to regulat...
How is Methyl 3-acetamido-2-thiophenecarboxylate (CAS: 22288-79-5) typically synthesized?
Methyl 3-acetamido-2-thiophenecarboxylate can be synthesized by the reaction of ...
What is 4-Isoquinolinecarbonitrile (CAS: 34846-65-6)?
4-Isoquinolinecarbonitrile is a chemical compound with the CAS number 34846-65-6...
How should Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) be stored?
Store Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) in a cool, dry p...
What regulatory guidelines apply to 6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8)?
6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8) is subject to the...
Is (2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) safe?
(2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) ...
What are the physical and chemical properties of 7-bromo-3-methyl-3,4-dihydroquinazolin-4-one (CAS: 1293987-84-4)?
7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one is a solid with a crystalline form....
Source Journal
Chemical Communications

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry











![6,6-Dimethylbicyclo[3.1.1]hept-2-ene-2-carbaldehyde structure 6,6-Dimethylbicyclo[3.1.1]hept-2-ene-2-carbaldehyde structure](https://static.chemtradehub.com/structs/564/564-94-3-e746.webp)
![8-Bromo-6-fluoro[1,2,4]triazolo[1,5-a]pyridin-2-amine structure 8-Bromo-6-fluoro[1,2,4]triazolo[1,5-a]pyridin-2-amine structure](https://static.chemtradehub.com/structs/125/1257705-51-3-9f4a.webp)

![[(2R)-6,6-Dimethyl-2-morpholinyl]methanol hydrochloride (1:1) structure [(2R)-6,6-Dimethyl-2-morpholinyl]methanol hydrochloride (1:1) structure](https://static.chemtradehub.com/structs/141/1416444-88-6-e06a.webp)