Oxy-peptide nucleic acid with a pyrrolidine ring that is configurationally optimized for hybridization with DNA

Literature Information

Publication Date 2004-04-23
DOI 10.1039/B401057D
Impact Factor 6.222
Authors

Mizuki Kitamatsu, Masanori Shigeyasu, Tomoyuki Okada, Masahiko Sisido


View Original

Abstract

Four stereoisomers of oxy-peptide nucleic acids containing ether linkages in the main chain and conformationally-restricted pyrrolidine rings (pyrrolidine-based oxy-PNA = POPNA) were newly synthesized and investigated for binding to DNA. cis-L-POPNA with 9 adenine bases formed the most stable hybrid with dT9. The POPNA showed high sequence specificity similar to that of the Nielsen-type PNA and sharper melting behavior in hybridization with DNA than the Nielsen-type PNA.

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