Study of the π–A isotherms of miltefosine monolayers spread at the air/water interface

Literature Information

Publication Date 2004-03-02
DOI 10.1039/B314439A
Impact Factor 3.676
Authors

I. Rey Gómez-Serranillos, J. Miñones Jr., P. Dynarowicz-Łątka, E. Iribarnegaray, M. Casas


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Abstract

Miltefosine (hexadecylphosphocholine), an anticancer drug based on a phospholipid-like structure, was spread and investigated at the aqueous solution/air interface as Langmuir monolayers by means of surface pressure–area (π–A) isotherms in addition to Brewster angle microscopy. The influence of such factors as subphase temperature, ionic strength, speed of compression, number of molecules spread at the surface on the characteristics of the π–A isotherms was studied. Miltefosine was found to form stable Langmuir monolayers which are nearly not influenced by experimental conditions. The liquid-expanded character of miltefosine films was confirmed with both compressibility modulus values and homogeneous BAM images. Ellipsometric measurements were performed to measure the thickness of miltefosine monolayer, and were used to calculate the orientation angle of miltefosine hydrophobic tail, which was found to change from 78.4 to 65.5 upon full monolayer compression. These results prove that the expanded character of miltefosine monolayer is due to the inclination of the molecule's hydrocarbon tail.

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Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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