Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers β-L-LNA and α-D-LNA; studies in the mirror image world
Literature Information
Nanna K. Christensen, Torsten Bryld, Mads D. Sørensen, Khalil Arar, Jesper Wengel, Poul Nielsen
Two LNA (locked nucleic acid) stereoisomers (β-L-LNA and α-D-LNA) are evaluated in the mirror-image world, that is by the study of two mixed sequences of LNA and α-L-LNA and their L-DNA and L-RNA complements. Both are found to display high-affinity RNA-recognition by the formation of duplexes with parallel strand orientation.
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