Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers β-L-LNA and α-D-LNA; studies in the mirror image world

Literature Information

Publication Date 2003-12-19
DOI 10.1039/B312321A
Impact Factor 6.222
Authors

Nanna K. Christensen, Torsten Bryld, Mads D. Sørensen, Khalil Arar, Jesper Wengel, Poul Nielsen


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Abstract

Two LNA (locked nucleic acid) stereoisomers (β-L-LNA and α-D-LNA) are evaluated in the mirror-image world, that is by the study of two mixed sequences of LNA and α-L-LNA and their L-DNA and L-RNA complements. Both are found to display high-affinity RNA-recognition by the formation of duplexes with parallel strand orientation.

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