The C-terminal ester of membrane anchored peptide ion channels affects anion transport

Literature Information

Publication Date 2003-10-23
DOI 10.1039/B312209N
Impact Factor 6.222
Authors

Natasha Djedovic, Riccardo Ferdani, Egan Harder, Jolanta Pajewska, Robert Pajewski, Paul H. Schlesinger, George W. Gokel


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Abstract

Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.

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