The C-terminal ester of membrane anchored peptide ion channels affects anion transport
Literature Information
Natasha Djedovic, Riccardo Ferdani, Egan Harder, Jolanta Pajewska, Robert Pajewski, Paul H. Schlesinger, George W. Gokel
Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.
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