Synthesis and Bergman cyclization of a β-extended porphyrenediyne
Literature Information
John D. Spence, Eric D. Cline, Domingo M. LLagostera, Patrick S. O'Toole
Condensation of a porphyrin-2,3-dione with a 1,2-diaminoarenediyne affords a β-extended porphyrinic-enediyne: upon thermal Bergman cyclization the quinoxaline spacer positioned between the macrocycle and the enediyne prevents tandem radical cyclization to a picenoporphyrin.
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![(4R,5S,6S)-3-({(3S,5S)-5-[(3-Carboxyphenyl)carbamoyl]-3-pyrrolidinyl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid structure (4R,5S,6S)-3-({(3S,5S)-5-[(3-Carboxyphenyl)carbamoyl]-3-pyrrolidinyl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid structure](https://static.chemtradehub.com/structs/153/153832-46-3-b2e0.webp)
![Bis(1,2,2,6,6-pentamethyl-4-piperidinyl) butyl[4-hydroxy-3,5-bis(2-methyl-2-propanyl)benzyl]malonate structure Bis(1,2,2,6,6-pentamethyl-4-piperidinyl) butyl[4-hydroxy-3,5-bis(2-methyl-2-propanyl)benzyl]malonate structure](https://static.chemtradehub.com/structs/638/63843-89-0-665e.webp)

