Practical synthesis of new and highly efficient ligands for the Suzuki reaction of aryl chlorides

Literature Information

Publication Date 2003-11-28
DOI 10.1039/B311268N
Impact Factor 6.222
Authors

Alexander Zapf, Ralf Jackstell, Franck Rataboul, Thomas Riermeier, Axel Monsees, Christa Fuhrmann, Nadim Shaikh, Uwe Dingerdissen, Matthias Beller


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Abstract

A practical synthesis of a novel class of phosphine ligands, phosphino substituted N-aryl pyrroles (PAP ligands), has been developed. These ligands are applied in the palladium-catalyzed coupling of a variety of aryl and heteroaryl chlorides with phenylboronic acid showing exceedingly high turnover numbers at mild reaction temperatures and even at room temperature.

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Chemical Communications

Chemical Communications
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