Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

Literature Information

Publication Date 2003-11-03
DOI 10.1039/B311008G
Impact Factor 6.222
Authors

Chris M. McGinley, Wilfred A. van der Donk


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Abstract

The oxidation of polyunsaturated fatty acids such as arachidonic and linoleic acid initiates a plethora of cell signaling pathways in animals and plants. The chemistry of the enzymatic oxidation has been investigated for several enzymes, most notably prostaglandin synthase and the lipoxygenases, revealing many surprises and impressive examples of enzymatic control of hydrogen atom abstraction and subsequent oxygenation.

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