Excellent enantio-selective enclathration of (2R,3S)-3-methyl-2-pentanol in channel-like cavity of 3-epideoxycholic acid, interpreted by the four-location model for chiral recognition
Literature Information
Kazuaki Kato, Kazuaki Aburaya, Yasuhito Miyake, Kazuki Sada, Norimitsu Tohnai, Mikiji Miyata
Pure (2R,3S)-3-methyl-2-pentanol is resolved from the racemates by a steroidal host; the interpretation of the recognition mechanism based on the crystal structure reveals that CH/O interaction between the host and guest plays a decisive role in enantio-selective enclathration of the small aliphatic secondary alcohol.
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