Extra amino group-containing gramicidin S analogs possessing outer membrane-permeabilizing activity

Literature Information

Publication Date 2003-04-29
DOI 10.1039/B302351F
Impact Factor 6.222
Authors

Masao Kawai, Ryoji Tanaka, Hatsuo Yamamura, Keiko Yasuda, Shizuto Narita, Hiroshi Umemoto, Setsuko Ando, Takashi Katsu


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Abstract

Novel (2S,4R)- and (2S,4S)-4-aminoproline residue-containing analogs of the cyclic decapeptide antibiotic gramicidin S were synthesized, which exhibited marked permeabilizing activity on the outer membrane of gram-negative bacteria.

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