Direction control in DNA binding of chiral d-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry

Literature Information

Publication Date 2003-04-02
DOI 10.1039/B212718K
Impact Factor 6.222
Authors

Stefano Sforza, Tullia Tedeschi, Roberto Corradini, Arnaldo Dossena, Rosangela Marchelli


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Abstract

The DNA binding abilities of peptide nucleic acids (PNAs), both achiral and bearing three adjacent D-lysine-based monomers in the middle of the strand (“chiral box” PNA), were studied by means of electrospray mass spectrometry (ESI-MS). In contrast with achiral PNA, “Chiral box” PNA was confirmed to exert high direction control (antiparallel vs. parallel DNA target) in DNA binding.

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