Direction control in DNA binding of chiral d-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry
Literature Information
Stefano Sforza, Tullia Tedeschi, Roberto Corradini, Arnaldo Dossena, Rosangela Marchelli
The DNA binding abilities of peptide nucleic acids (PNAs), both achiral and bearing three adjacent D-lysine-based monomers in the middle of the strand (“chiral box” PNA), were studied by means of electrospray mass spectrometry (ESI-MS). In contrast with achiral PNA, “Chiral box” PNA was confirmed to exert high direction control (antiparallel vs. parallel DNA target) in DNA binding.
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