The levelling effect of solvational imbalances in the reactions of oximate α-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of organophosphorus esters

Literature Information

Publication Date 2003-02-04
DOI 10.1039/B212160N
Impact Factor 6.222
Authors

F. Terrier, E. Le Guével, A. P. Chatrousse, G. Moutiers, E. Buncel


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Abstract

A study of the reactions of oximate α-nucleophiles with diisopropylphosphorofluoridate (DFP) and two model phosphonates, has revealed either a levelling-off in reactivity or a bell-shaped behaviour in accordance with a critical decoupling of desolvation and bond formation (solvational imbalances); the relevance of these results to detoxification is emphasized.

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