Sarocladione, a unique 5,10:8,9-diseco-steroid from the deep-sea-derived fungus Sarocladium kiliense

Literature Information

Publication Date 2019-05-29
DOI 10.1039/C9OB01159E
Impact Factor 3.876
Authors

Chun-Lan Xie, Jin-Mei Xia, Cui-Ping Xing, Zhu-Hua Luo, Zongze Shao, Xiao-Jun Yan, Shan He, Xian-Wen Yang


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Abstract

A novel ergostane, sarocladione (1), was isolated from the deep-sea-derived fungus Sarocladium kiliense, along with 20 known compounds. The structure of 1 was determined mainly by a detailed analysis of its experimental and calculated NMR spectroscopic data. It is worth noting that 1 was the first steroid bearing a 5,10:8,9-diseco moiety. All 21 compounds were tested for in vitro antitumor activities against five cancer cell lines. β-Sitostenone (7) and 4,6-dihydroxyeudesmane (20) showed significant effects on HeLa-S3 cells with the IC50 values of 9.2 μM and 9.3 μM, respectively.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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