A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids

Literature Information

Publication Date 2003-01-20
DOI 10.1039/B210673F
Impact Factor 6.222
Authors

Darren J. Dixon, Christopher I. Harding, Steven V. Ley, D. Matthew G. Tilbrook


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Abstract

A new chiral glycine equivalent 7 has been synthesised from glycidol using a chiral memory protocol, and its use in the synthesis of N-Z protected α-amino acids was demonstrated in a series of diasteroselective lithium enolate alkylation reactions and subsequent acid hydrolyses.

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