Raman structural study of thymine and its 2′-deoxy-ribosyl derivatives in solid state, aqueous solution and when adsorbed on silver nanoparticles
Literature Information
Laura Rivas, Santiago Sánchez-Cortés, José V. García-Ramos
The structures of thymine, 2′-deoxythymidine (dT), 5′-thymidinemonophosphate (TMP) and the anti-HIV drug 3′-azido-3′-deoxythymidine (AZT) are studied in this work in solid state, aqueous solution and when these molecules are adsorbed on Ag colloids by means of Raman and surface-enhanced Raman spectroscopy (SERS). The presence of a ribosyl group in the thymine N(1) position induces a change in the electrodynamical properties of the corresponding nucleosides and nucleotides of this base resulting in a different adsorption on the metal. In addition, the presence of substituents such as phosphate in TMP and azido group in AZT influences significantly the conformation of these molecules in solid state, in aqueous solution and adsorbed on the metal surface, as well as the orientation that they adopt on the metal. The molecular conformation of these thymine derivatives has an important significance because of the relationship existing between structure and biological activity.
Related Literature
Low impact synthesis of β-nitroacrylates under fully heterogeneous conditions
Alessandro Palmieri, Serena Gabrielli, Roberto Ballini
DOI: 10.1039/C3GC40936H
N-terminal PEGylated cellulase: a high stability enzyme in 1-butyl-3-methylimidazolium chloride
Lu Li, Juan Xie, Shitao Yu, Zhongliang Su, Shiwei Liu, Fusheng Liu, Congxia Xie, Baoquan Zhang, Chenggang Zhang
DOI: 10.1039/C3GC40104A
Iodine-mediated arylation of benzoxazoles with aldehydes
Yew Chin Teo, Siti Nurhanna Riduan, Yugen Zhang
DOI: 10.1039/C3GC41027G
Retracted Article: One-pot synthesis of glycidol from glycerol and dimethyl carbonate over a highly efficient and easily available solid catalyst NaAlO2
Rongxian Bai, Hongkun Zhang, Fuming Mei, Shu Wang, Tao Li, Guangxing Li
DOI: 10.1039/C3GC40855H
Chemical conversion of biomass-derived hexose sugars to levulinic acid over sulfonic acid-functionalized graphene oxide catalysts
Ji-Woong Yoon, Dong Won Hwang, Harold H. Kung
DOI: 10.1039/C3GC40353J
Ionic liquid confined zeolite system: an approach towards water mediated room temperature synthesis of spiro[pyrazolo[3,4-e]benzothiazepines]
Kapil Arya, Biswajeet Prabhakar
DOI: 10.1039/C3GC40553B
Palladium-, ligand-, and solvent-free synthesis of ynones by the coupling of acyl chlorides and terminal alkynes in the presence of a reusable copper nanoparticle catalyst
Weijiang Sun, Yan Wang, Xuan Wu, Xiaoquan Yao
DOI: 10.1039/C3GC40980E
Stereoselective organic reactions promoted by immobilized chiral catalysts in continuous flow systems
Alessandra Puglisi, Maurizio Benaglia, Valerio Chiroli
DOI: 10.1039/C3GC40195B
Development of GSK's reagent guides – embedding sustainability into reagent selection
Joseph P. Adams, Catherine M. Alder, Ian Andrews, Ann M. Bullion, Matthew Campbell-Crawford, Michael G. Darcy, John D. Hayler, Richard K. Henderson, Catriona A. Oare, Israil Pendrak, Anikó M. Redman, Leanna E. Shuster, Helen F. Sneddon, Matthew D. Walker
DOI: 10.1039/C3GC40225H
Benzoylation for the recovery of structure directing agent (di-n-propylamine) from the process effluent of aluminophosphate synthesis
Nageswara N. Rao, Smita Masid
DOI: 10.1039/C3GC40759D
You might also like
What precautions should be taken when handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3)?
When handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3), safety go...
What is 4-(3,5-Difluorophenyl)aniline (CAS: 405058-00-6)?
4-(3,5-Difluorophenyl)aniline is an aromatic organic compound with the CAS numbe...
How is 5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid (CAS: 338982-07-3) typically synthesized?
5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid can ...
What is the market or research trend for 4-Benzylaniline hydrochloride (CAS: 6317-57-3)?
The market for 4-Benzylaniline hydrochloride (CAS: 6317-57-3) is steadily growin...
Is [3-(Diethylsulfamoyl)phenyl]boronic acid (CAS: 871329-58-7) safe?
[3-(Diethylsulfamoyl)phenyl]boronic acid is generally considered safe when handl...
What are the main uses of 3-Bromo-2,5-dimethoxyaniline (CAS: 115929-62-9)?
3-Bromo-2,5-dimethoxyaniline is mainly used in the pharmaceutical and chemical i...
What regulatory guidelines apply to N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7)?
N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7) is subject to ...
What industries use Carbamic acid, N-[(5S)-5,6-diamino-6-oxohexyl]-, 1,1-dimethylethyl ester (CAS: 24828-96-4)?
This compound is primarily used in the pharmaceutical industry for the synthesis...
How should 2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) be stored?
2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) sho...
What industries use Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9)?
Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9) is utilized in the pharma...
Source Journal
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.











![N-{3-[Benzyl(methyl)amino]propyl}-9-chloro-5,6,7,8-tetrahydro-2-acridinecarboxamide structure N-{3-[Benzyl(methyl)amino]propyl}-9-chloro-5,6,7,8-tetrahydro-2-acridinecarboxamide structure](https://static.chemtradehub.com/structs/142/1426944-49-1-1e4c.webp)
![[3-(2,6-Dichlorophenyl)-5-isopropyl-1,2-oxazol-4-yl]methanol structure [3-(2,6-Dichlorophenyl)-5-isopropyl-1,2-oxazol-4-yl]methanol structure](https://static.chemtradehub.com/structs/278/278597-30-1-5c79.webp)

