Raman structural study of thymine and its 2′-deoxy-ribosyl derivatives in solid state, aqueous solution and when adsorbed on silver nanoparticles

Literature Information

Publication Date 2002-04-16
DOI 10.1039/B110564G
Impact Factor 3.676
Authors

Laura Rivas, Santiago Sánchez-Cortés, José V. García-Ramos


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Abstract

The structures of thymine, 2′-deoxythymidine (dT), 5′-thymidinemonophosphate (TMP) and the anti-HIV drug 3′-azido-3′-deoxythymidine (AZT) are studied in this work in solid state, aqueous solution and when these molecules are adsorbed on Ag colloids by means of Raman and surface-enhanced Raman spectroscopy (SERS). The presence of a ribosyl group in the thymine N(1) position induces a change in the electrodynamical properties of the corresponding nucleosides and nucleotides of this base resulting in a different adsorption on the metal. In addition, the presence of substituents such as phosphate in TMP and azido group in AZT influences significantly the conformation of these molecules in solid state, in aqueous solution and adsorbed on the metal surface, as well as the orientation that they adopt on the metal. The molecular conformation of these thymine derivatives has an important significance because of the relationship existing between structure and biological activity.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
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Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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