Ripasudil hydrochloride dihydrate

Basic Information

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CAS Number

887375-67-9

Molecular Formula

C15H23ClFN3O4S

Molecular Weight

395.88 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)F.O.O.Cl

InChI

InChI=1S/C15H18FN3O2S.ClH.2H2O/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14;;;/h2,4-5,9-11,17H,3,6-8H2,1H3;1H;2*1H2/t11-;;;/m0.../s1

InChIKey

CMDJNMACGABCKQ-XVSRHIFFSA-N

LogP

0.5187999999999995

Topological Polar Surface Area

125.30000000000001 Å²

Hydrogen Bond Donor/Acceptor

5 / 7

Complexity

482

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

K115
K-115 Hydrochloride Dihydrate
Ripasudil
K-115
Ripasudil hydrochloride dihydrate
016TTR32QF
Ripasudil hydrochloride hydrate [JAN]
Ripasudil hydrochloride hydrate (JAN)
Ripasudil hydrochloride hydrate
Glanatec (TN)
Ripasudil hydrochloride dihydrate [WHO-DD]
C15H18FN3O2S.ClH.2H2O
BCP11082
s7995
3757AH
1H-1,4-Diazepine, 1-((4-fluoro-5-is
1H-1,4-Diazepine, 1-[(4-fluoro-5-isoquinolinyl)sulfonyl]hexahydro-2-methyl-, monohydrochloride, dihydrate, (2S)- (9CI)
Ripasudil monohydrochloride dihydrate
HY-15685
Ripasudil(K-115)
glanatec
4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;dihydrate;hydrochloride
CHEMBL4594454
AS-55803
AKOS027338678
ripasudil hydrochloride
RIPASUDIL HYDROCHLORIDE DIHYDRATE [MI]
4-fluoro-5-{[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline dihydrate hydrochloride
CS-3401
Ripasudil (K-115) hydrochloride di
DB-102202

MDL Number

MFCD26960897

FAQ

What regulatory guidelines apply to Ripasudil hydrochloride dihydrate (CAS: 887375-67-9)?

Ripasudil hydrochloride dihydrate (CAS: 887375-67-9) should comply with GHS classification, REACH regulations, and FDA/EPA requirements. Manufacturers and importers must ensure it meets the specific criteria for classification, labeling, and packaging as outlined in the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) and the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation. Additionally, FDA and EPA regulations are essential for its safe handling and environmental impact assessment.

Are there alternatives to Ripasudil hydrochloride dihydrate (CAS: 887375-67-9) in synthesis?

There are several alternatives to Ripasudil hydrochloride dihydrate (CAS: 887375-67-9) in synthesis, such as analogs like Ripasudil trihydrochloride and isomers. Common alternative reagents include 2-(2-hydroxyethoxy)ethanamine hydrochloride and 4-(2-(2-hydroxyethoxy)ethoxy)benzene-1-sulfonamide. These alternatives can offer similar pharmacological activities with variations in solubility, stability, and synthesis efficiency.

What is the market or research trend for Ripasudil hydrochloride dihydrate (CAS: 887375-67-9)?

The market for Ripasudil hydrochloride dihydrate (CAS: 887375-67-9) is growing due to its potential in treating glaucoma and other ocular hypertension conditions. Research trends focus on its efficacy, safety, and second-line treatment options. Emerging studies are exploring its application in cardiovascular and neurodegenerative diseases, driving further market expansion and innovation.

How should waste containing Ripasudil hydrochloride dihydrate (CAS: 887375-67-9) be handled?

Waste containing Ripasudil hydrochloride dihydrate (CAS: 887375-67-9) should be collected in appropriate containers, labeled with the chemical name and CAS number, and stored in a secure and well-ventilated area. It should be disposed of by incineration or professional waste disposal services that adhere to environmental regulations. Precautions include proper personal protective equipment (PPE) and following local waste management guidelines to minimize environmental impact.