N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine

Basic Information

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CAS Number

77284-32-3

Molecular Formula

C21H23NO4

Molecular Weight

353.42 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

141-144 °C

Boiling Point

565.6°C at 760 mmHg

Density

1.209

Flash Point

295.9°C

Specific Rotation

-18.5 º (c=1 in DMF)

SMILES

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CCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C21H23NO4/c1-2-3-12-19(20(23)24)22-21(25)26-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,2-3,12-13H2,1H3,(H,22,25)(H,23,24)/t19-/m0/s1

InChIKey

VCFCFPNRQDANPN-IBGZPJMESA-N

LogP

4.1685000000000025

Topological Polar Surface Area

75.63 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

472

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

Fmoc-L-norleucine
AS-18993
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid
VCFCFPNRQDANPN-IBGZPJMESA-N
(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)hexanoic acid
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid
Fmoc-Nle
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)hexanoic acid
N-(9-Fluorenylmethoxycarbonyl)-L-norleucine
Fmoc-(S)-2-aminohexanoic acid
N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-norleucine
AKOS016842954
HY-W008688
Q-101634
AM82590
FmocNleOH
Z1900782536
1-(5-Chloropyrimidin-2-yl)-N-methyl-d3-methanamine
Fmoc-L-Nle-OH
CS-W009404
SCHEMBL1000115
77284-32-3
MFCD00037537
Fmoc-L-norleucine Fmoc-Nle-OH
(S)-2-(Fmoc-amino)caproic acid
(S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-HEXANOIC ACID
J-300350
Fmoc-L-2-aminocaproic acid
EN300-316895
Fmoc-Nle-OH, >=98.0% (sum of enantiomers, HPLC)
AU-004/43510510

MDL Number

MFCD00037537

Customs Code

2924299090

FAQ

What is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine (CAS: 77284-32-3)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine is a peptide derivative with a fluorenylmethoxycarbonyl (Fmoc) group attached to the α-amino group of norleucine. This compound is commonly used in peptide synthesis and research.

What are the main uses of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine (CAS: 77284-32-3)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine is primarily used in the synthesis of peptides, serving as a protecting group. It is also employed in research for its ability to modify the properties of peptides.

Is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine (CAS: 77284-32-3) safe?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine is generally considered safe for laboratory use when handled with appropriate precautions. It is not highly toxic, but it should be stored in a cool, dry place away from light and handled with gloves to avoid skin contact.

How should N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine (CAS: 77284-32-3) be stored?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine should be stored in a cool, dry place away from direct sunlight and moisture. Keep the compound in a tightly sealed container to prevent degradation. It is recommended to store it at room temperature (20-25°C) to ensure stability.