(R)-(+)-Tolvaptan

Basic Information

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CAS Number

331947-66-1

Molecular Formula

C26H25ClN2O3

Molecular Weight

448.95 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C

InChI

InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)/t24-/m1/s1

InChIKey

GYHCTFXIZSNGJT-XMMPIXPASA-N

LogP

5.683140000000005

Topological Polar Surface Area

69.64 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

674

Synonyms & References

English

(R)-(+)-Tolvaptan
(+)-Tolvaptan
N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
Benzamide, N-[4-[[(5R)-7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl]carbonyl]-3-methylphenyl]-2-methyl-
CHEMBL4303142
N-[4-[(5R)-7-chloro-5-hydroxy2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide
Tolvaptan, (R)-
D01213
MFCD09838782
DB06212
NCGC00379011-01
Tolvaptan (JAN/USAN/INN)
DTXSID00332136
Z1558515750
NCGC00183001-03
SMR004703534
MLS006011965
EN300-124249
(R)-(+)-OPC-41061
N-[4-[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide
Benzamide, N-(4-(((5R)-7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-3-methylphenyl)-2-methyl-
SCHEMBL1650272
1E2497LPNY
N-[4-[[(5S)-7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl]carbonyl]-3-methylphenyl]-2-methylbenzamide; (S)-(-)-OPC 41061
N-{4-[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl]-3-methylphenyl}-2-methylbenzamide
NS00004184
331947-66-1
N-[4-[[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepin-1-yl]-oxomethyl]-3-methylphenyl]-2-methylbenzamide
(+)-TOLVAPTAN
EX-A1126
CS-0133297

MDL Number

MFCD09837707

FAQ

What is (R)-(+)-Tolvaptan (CAS: 331947-66-1)?

(R)-(+)-Tolvaptan (CAS: 331947-66-1) is a selective vasopressin V2 receptor antagonist. It is used primarily in the treatment of hyponatremia and is also studied for other potential applications. The compound is optically active and belongs to the class of organic compounds.

What are the main uses of (R)-(+)-Tolvaptan (CAS: 331947-66-1)?

(R)-(+)-Tolvaptan (CAS: 331947-66-1) is primarily used for the treatment of hyponatremia, a condition characterized by low sodium levels in the blood. It is also being explored for other potential uses such as the treatment of fibrosis and other conditions related to kidney function.

Is (R)-(+)-Tolvaptan (CAS: 331947-66-1) safe?

(R)-(+)-Tolvaptan (CAS: 331947-66-1) is generally considered safe when used as directed for the treatment of hyponatremia. However, it is important to follow medical guidance and take precautions to avoid potential side effects such as hypokalemia (low potassium levels) and dehydration. Always consult a healthcare provider for safe use.

How should (R)-(+)-Tolvaptan (CAS: 331947-66-1) be stored?

(R)-(+)-Tolvaptan (CAS: 331947-66-1) should be stored in a tightly closed container at room temperature (15-30°C) and protected from direct sunlight. It is important to keep the medication away from moisture and heat to maintain its efficacy and safety.