Pyrazolo[1,5-a]pyridine

Basic Information

View in Editor

CAS Number

274-56-6

Molecular Formula

C7H6N2

Molecular Weight

118.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Liquid

Boiling Point

210.6℃ at 760 mmHg

Refractive Index

1.6075

SMILES

View in Editor

C1=CC2=CC=NN2C=C1

InChI

InChI=1S/C7H6N2/c1-2-6-9-7(3-1)4-5-8-9/h1-6H

InChIKey

DVUBDHRTVYLIPA-UHFFFAOYSA-N

LogP

1.3342999999999998

Topological Polar Surface Area

17.3 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

103

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

A819072
DTXSID10181819
AM20051032
6,7a-dimethyl-2,3,5,6-tetrahydrooxazolo[2,3-b]oxazole;Pyrazolo[1,5-a]pyridine
Pyrazolo(1,5-a)pyridine
EN300-108139
Pyrazolo[1,5-a]pyridine
CHEMBL577543
3-Azaindoline
DS-16354
SCHEMBL31391
FT-0693895
3-Azaindolizine
Pyrazolo[2,3-a]pyridine
F2199-0104
AKOS006290545
AB48944
MFCD08752622
SY007594
Pyrazolo(2,3-a)pyridine
CS-B0647
274-56-6
H-PYRAZOLO[1,5-A]PYRIDINE
pyrazolo<5,1-a>pyridine
DVUBDHRTVYLIPA-UHFFFAOYSA-N
pyrazolo[1,5-a]-pyridine
Pyrazolo[1,5-apyridine
TRA0072985
EN000995
ST2419810
AB0070581

MDL Number

MFCD08752622

Customs Code

2933990090

FAQ

What are the physical and chemical properties of Pyrazolo[1,5-a]pyridine (CAS: 274-56-6)?

Pyrazolo[1,5-a]pyridine (CAS: 274-56-6) is a crystalline solid with a molecular weight of approximately 123.12 g/mol. It is slightly soluble in water and organic solvents like dimethylformamide (DMF) and acetonitrile. Chemically, it is relatively stable but can undergo nucleophilic substitution reactions. Its melting point is around 240°C, and it is commonly used in pharmaceutical and industrial applications.

How is Pyrazolo[1,5-a]pyridine (CAS: 274-56-6) typically synthesized?

Pyrazolo[1,5-a]pyridine (CAS: 274-56-6) is typically synthesized via the condensation of 1H-pyrazole and 2,6-dichloropyridine. Aqueous solutions of these precursors are heated to reflux in the presence of a base such as potassium carbonate. The reaction yields high selectivity and good yield, making it a common method in synthesis labs.

What industries use Pyrazolo[1,5-a]pyridine (CAS: 274-56-6)?

Pyrazolo[1,5-a]pyridine (CAS: 274-56-6) is widely used in the pharmaceutical industry for its potential as a drug candidate due to its biological activity. It is also utilized in the polymer industry for its potential as a monomer, in sensor technology for its sensing capabilities, and in the semiconductor industry for its electronic properties.

What precautions should be taken when handling Pyrazolo[1,5-a]pyridine (CAS: 274-56-6)?

When handling Pyrazolo[1,5-a]pyridine (CAS: 274-56-6), it is important to wear appropriate personal protective equipment (PPE) such as gloves and eye protection. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately following the manufacturer’s safety data sheet (SDS) guidelines. Ensure proper disposal and storage to avoid environmental contamination.