Polypropylene Glycol (P 400) | CAS No. 25322-69-4

Q: What is Polypropylene Glycol (P 400) (CAS: 25322-69-4)?

Polypropylene Glycol (P 400), with CAS number 25322-69-4, is a clear, viscous liquid derived from propylene oxide. It has a molecular weight of approximately 400 g/mol and is characterized by its hydrophilic nature, low toxicity, and chemical stability. Commonly used as a solvent, emulsifier, and viscosity modifier, P 400 is widely applied in pharmaceuticals, food, and industrial sectors due to its biocompatibility and inert properties.

Q: What are the main uses of Polypropylene Glycol (P 400) (CAS: 25322-69-4)?

Polypropylene Glycol (P 400) (CAS: 25322-69-4) is primarily used in pharmaceuticals as a solubilizing agent and excipient, in food as a humectant and emulsifier, and in industrial applications such as lubricants, coatings, and plasticizers. It also serves as a carrier in research for drug delivery systems and chemical synthesis. Its versatility makes it a key component in various formulations and processes.

Q: Is Polypropylene Glycol (P 400) (CAS: 25322-69-4) safe?

Polypropylene Glycol (P 400) (CAS: 25322-69-4) is generally recognized as safe (GRAS) by the FDA for food contact and meets USP standards for pharmaceutical use. It has low toxicity and is non-irritating, but proper handling is essential to avoid inhalation or skin contact. Safety measures include using gloves, ensuring adequate ventilation, and following standard operating procedures for chemical handling.

Q: How should Polypropylene Glycol (P 400) (CAS: 25322-69-4) be stored?

Polypropylene Glycol (P 400) (CAS: 25322-69-4) should be stored in a cool, dry place away from light and heat sources. Maintain storage temperature between 15-25°C and keep humidity levels low to prevent degradation. Ensure the container is tightly sealed and stored in a well-ventilated area, avoiding contact with incompatible materials to preserve stability and safety.

Polypropylene Glycol (P 400)

Basic Information

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CAS Number

25322-69-4

Molecular Formula

C6H14O3

Molecular Weight

134.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

Melting Point

-31 ºC

Boiling Point

234.2°C at 760 mmHg

Solubility

H2O: <0.01 % (w/w) at 25 °C

Refractive Index

n20/D 1.450

Vapor Pressure

<0.01 mmHg ( 20 °C)

SMILES

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CC(CO)OCC(C)O

InChI

InChI=1S/C6H14O3/c1-5(8)4-9-6(2)3-7/h5-8H,3-4H2,1-2H3

InChIKey

DUFKCOQISQKSAV-UHFFFAOYSA-N

LogP

-0.23540

Complexity

65.3

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Stable. Substances to be avoided include strong oxidizing agents.

Synonyms & References

English

Poly[oxy(methyl-1,2-ethanediyl)], a-hydro-w-hydroxy-
NS00008462
2-(2-hydroxypropoxy)propan-1-ol
DTXSID30861722
Laprol 2002
EINECS 203-416-2
FT-0696553
1-Propanol, 2-(2-hydroxypropoxy)-
Napter E 8075
CHEBI:53262
Niax ppg 1025
AKOS015899603
Q26863457
2-(2-HYDROXYPROPOXY)-1-PROPANOL
CHEBI:179442
Jeffox PPG 400
106-62-7
PPG?
BS-23535
Lineartop E
25322-69-4
Desmophen 360C
Niax ppg 3025
2-(2-Hydroxypropoxy)propanol
F71159
Emkapyl
SCHEMBL15111
WNY0H4G53Q
UNII-WNY0H4G53Q
Laprol 702
Niax ppg

MDL Number

MFCD00084446

FAQ

What is Polypropylene Glycol (P 400) (CAS: 25322-69-4)?

Polypropylene Glycol (P 400), with CAS number 25322-69-4, is a clear, viscous liquid derived from propylene oxide. It has a molecular weight of approximately 400 g/mol and is characterized by its hydrophilic nature, low toxicity, and chemical stability. Commonly used as a solvent, emulsifier, and viscosity modifier, P 400 is widely applied in pharmaceuticals, food, and industrial sectors due to its biocompatibility and inert properties.

What are the main uses of Polypropylene Glycol (P 400) (CAS: 25322-69-4)?

Polypropylene Glycol (P 400) (CAS: 25322-69-4) is primarily used in pharmaceuticals as a solubilizing agent and excipient, in food as a humectant and emulsifier, and in industrial applications such as lubricants, coatings, and plasticizers. It also serves as a carrier in research for drug delivery systems and chemical synthesis. Its versatility makes it a key component in various formulations and processes.

Is Polypropylene Glycol (P 400) (CAS: 25322-69-4) safe?

Polypropylene Glycol (P 400) (CAS: 25322-69-4) is generally recognized as safe (GRAS) by the FDA for food contact and meets USP standards for pharmaceutical use. It has low toxicity and is non-irritating, but proper handling is essential to avoid inhalation or skin contact. Safety measures include using gloves, ensuring adequate ventilation, and following standard operating procedures for chemical handling.

How should Polypropylene Glycol (P 400) (CAS: 25322-69-4) be stored?

Polypropylene Glycol (P 400) (CAS: 25322-69-4) should be stored in a cool, dry place away from light and heat sources. Maintain storage temperature between 15-25°C and keep humidity levels low to prevent degradation. Ensure the container is tightly sealed and stored in a well-ventilated area, avoiding contact with incompatible materials to preserve stability and safety.