Poly-L-leucine

Basic Information

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CAS Number

25322-63-8

Molecular Formula

C6H13NO2

Molecular Weight

131.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

300 ºC

SMILES

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CC(CC(C(=O)O)N)C

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)

InChIKey

ROHFNLRQFUQHCH-UHFFFAOYSA-N

LogP

0.44439999999999996

Topological Polar Surface Area

63.31999999999999 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

101

Synonyms & References

English

Poly-L-leucine
POLY-L-LEUCINE MW 3000-15000
poly-L-leucine 3000-15000
poly-L-leucine mol wt 100000-150000
Poly(iminocarbonylisopentylidene),L- (8CI)
Poly[imino[1-(2-methylpropyl)-2-oxo-1,2-ethanediyl]], (S)-
L-Leucinepolymer, SRU
Poly(L-leucine), SRU
Polyleucine
Polyleucine,SRU

MDL Number

MFCD00166370

FAQ

What are the physical and chemical properties of Poly-L-leucine (CAS: 25322-63-8)?

Poly-L-leucine (CAS: 25322-63-8) is a linear polymer with a crystalline form. It has a high molecular weight, typically ranging from 10 kDa to 100 kDa. This polymer is poorly soluble in water but soluble in organic solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). It is moderately reactive, showing limited reactivity with nucleophiles such as thiols and amines. Its physicochemical properties make it useful in various applications such as drug delivery systems and biocompatible materials.

How is Poly-L-leucine (CAS: 25322-63-8) typically synthesized?

Poly-L-leucine (CAS: 25322-63-8) is synthesized by polymerization of L-leucine monomers. Common methods include solid-phase peptide synthesis using Fmoc chemistry or liquid-phase synthesis with N-carboxyanhydride (NCN) methods. The polymerization is typically carried out in a solvent such as DMF or DMSO under mild conditions. The yield and selectivity of the polymerization can be controlled by the choice of coupling agent and reaction conditions.

What industries use Poly-L-leucine (CAS: 25322-63-8)?

Poly-L-leucine (CAS: 25322-63-8) is used in various industries. In pharmaceuticals, it serves as a scaffold for drug delivery systems and in the development of bioactive materials. In the polymer industry, it is used to create biodegradable polymers. It also finds applications in sensors and semiconductors due to its unique physicochemical properties. Additionally, it is utilized in biotechnology for protein engineering and as a model polymer in studies of protein-protein interactions.

What precautions should be taken when handling Poly-L-leucine (CAS: 25322-63-8)?

When handling Poly-L-leucine (CAS: 25322-63-8), it is important to use appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Work should be conducted in a well-ventilated area or in a fume hood to minimize inhalation risk. Spills should be cleaned up carefully, using appropriate absorbent materials. In case of contact, wash the affected area with copious amounts of water. It is advisable to refer to the Safety Data Sheet (SDS) for specific safety information and guidelines. Poly-L-leucine is not considered hazardous under normal laboratory conditions, but handling should be done with caution to avoid accidental ingestion or inhalation.