1-(3,4,5-Trifluorophenyl)methanamine

Basic Information

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CAS Number

235088-69-4

Molecular Formula

C7H6F3N

Molecular Weight

161.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Refractive Index

1.4736

SMILES

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C1=C(C=C(C(=C1F)F)F)CN

InChI

InChI=1S/C7H6F3N/c8-5-1-4(3-11)2-6(9)7(5)10/h1-2H,3,11H2

InChIKey

AJGBQAAXUVSBCH-UHFFFAOYSA-N

LogP

1.5626

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

119

Safety Information

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Hazard Statement

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

SB75868
DTXSID50380349
FT-0614145
EN300-1611701
CK2434
(3,4,5-trifluorophenyl)methylamine
Benzenemethanamine, 3,4,5-trifluoro-
3,4,5-Trifluorobenzylamine
AJGBQAAXUVSBCH-UHFFFAOYSA-N
AKOS009157406
3,4,5-Trifluorobenzylamine, AldrichCPR
235088-69-4
(3,4,5-trifluorophenyl)methanamine
DS-4556
3,4,5-trifluorobenzyl amine
MFCD00236318
1-(3,4,5-trifluorophenyl)methanamine
SY062291
BDBM626031
AC-17019
J-015132
A816755
SCHEMBL1764604
CS-W014325
(3,4,5-Trifluorophenyl)methanamine
3, 4, 5-trifluorobenzylamine
PubChem7403
RARECHEM AL BW 0701
Benzenemethanamine,3,4,5-trifluoro-
SBB087498
1584AB

MDL Number

MFCD00236318

Customs Code

2921499090

FAQ

What are the physical and chemical properties of 1-(3,4,5-Trifluorophenyl)methanamine (CAS: 235088-69-4)?

1-(3,4,5-Trifluorophenyl)methanamine is a colorless to white crystalline solid with a molecular weight of approximately 186.08 g/mol. It is poorly water-soluble but has good solubility in organic solvents like dichloromethane and ethanol. This compound exhibits moderate reactivity towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but requires handling under an inert atmosphere to prevent degradation.

How is 1-(3,4,5-Trifluorophenyl)methanamine (CAS: 235088-69-4) typically synthesized?

1-(3,4,5-Trifluorophenyl)methanamine is typically synthesized via the Mannich reaction, where 3,4,5-trifluorobenzaldehyde, dimethylamine, and formic acid are combined in the presence of a base such as sodium hydroxide. The reaction yields the desired amine with good yield and selectivity. This method is commonly used in the synthesis of various trifluorophenyl-containing compounds for pharmaceutical applications.

What industries use 1-(3,4,5-Trifluorophenyl)methanamine (CAS: 235088-69-4)?

1-(3,4,5-Trifluorophenyl)methanamine is primarily used in the pharmaceutical industry for the development of drug candidates. Its unique chemical structure makes it useful in the synthesis of drugs targeting various diseases. Additionally, it is used in the polymer industry for the modification of polymers to improve their properties. It also finds applications in the electronics industry for preparing sensors and semiconductors.

What precautions should be taken when handling 1-(3,4,5-Trifluorophenyl)methanamine (CAS: 235088-69-4)?

Precautions when handling 1-(3,4,5-Trifluorophenyl)methanamine include wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a fume hood to minimize exposure. Spills should be cleaned up with caution using appropriate absorbents. In case of contact, flush the affected area with water and seek medical advice. Always refer to the Safety Data Sheet (SDS) for specific guidelines and emergency procedures.