Fluorescein-6-isothiocyanate

Basic Information

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CAS Number

18861-78-4

Molecular Formula

C21H11NO5S

Molecular Weight

389.39 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

No data available

Melting Point

No data available

Boiling Point

719.1±60.0 °C at 760 mmHg

Density

3.7000

Flash Point

388.7±32.9 °C

SMILES

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C1=CC2=C(C=C1N=C=S)C3(C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O)OC2=O

InChI

InChI=1S/C21H11NO5S/c23-12-2-5-15-18(8-12)26-19-9-13(24)3-6-16(19)21(15)17-7-11(22-10-28)1-4-14(17)20(25)27-21/h1-9,23-24H

InChIKey

GTQFZXYECNSNNC-UHFFFAOYSA-N

LogP

4.400100000000003

Topological Polar Surface Area

88.35000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

668

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

6-Isothiocyanatofluorescein
F0783
6-FITC [MI]
Fluorescein-6-isothiocyanate
PD167109
F6ITC
F12301
FT-0626458
Fluorescein 6-Isothiocyanate (isomer II)
AKOS015912141
3',6'-dihydroxy-6-isothiocyanato-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
3',6'-dihydroxy-6-isothiocyanato-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one
J-012159
HY-136957
18861-78-4
NS00049477
MFCD00041838
CS-0135568
Fluorescein 6-Isothiocyanate, Isomer 2, 95%
SCHEMBL160107
3',6'-dihydroxy-5-isothiocyanatospiro[2-benzofuran-3,9'-xanthene]-1-one
fluorescein 6-isothiocyanate
DTXSID10293325
CHEBI:37928
fluorescein isothiocyanate isomer ii
LS-14835
F04-0026
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,3',6'-dihydroxy-6-isothiocyanato-
FITC isomer II [Fluorescein-6-isothiocyanate]
6-FITC
6-FITC (isomer II)

MDL Number

MFCD00041838

Customs Code

2932999099

FAQ

What regulatory guidelines apply to Fluorescein-6-isothiocyanate (CAS: 18861-78-4)?

Fluorescein-6-isothiocyanate (CAS: 18861-78-4) is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), REACH in the European Union, and FDA and EPA requirements in the United States. It is classified as a skin and eye irritant and requires proper labeling and handling to comply with these regulations.

Are there alternatives to Fluorescein-6-isothiocyanate (CAS: 18861-78-4) in synthesis?

Yes, there are several alternatives to Fluorescein-6-isothiocyanate (CAS: 18861-78-4) in synthesis, including other thioisocyanates like o-phenylenediamine-4-isothiocyanate and various fluorescein derivatives. These alternatives can be chosen based on the specific requirements of the synthesis, such as reactivity and stability.

What is the market or research trend for Fluorescein-6-isothiocyanate (CAS: 18861-78-4)?

The market for Fluorescein-6-isothiocyanate (CAS: 18861-78-4) is driven by its applications in fluorescence labeling and imaging in life sciences research. Recent research trends include its use in protein and RNA labeling, as well as in flow cytometry and fluorescence microscopy. The demand is expected to grow due to increasing investment in biological research and diagnostics.

How should waste containing Fluorescein-6-isothiocyanate (CAS: 18861-78-4) be handled?

Waste containing Fluorescein-6-isothiocyanate (CAS: 18861-78-4) should be collected in appropriate containers and disposed of according to local hazardous waste regulations. Incineration or professional waste disposal services are recommended to ensure safe and environmentally friendly disposal. Proper protective measures, such as gloves and goggles, should be worn during handling to prevent skin and eye irritation.