3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(4-morpholinylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one | CAS No. 1513857-77-6
3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(4-morpholinylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
Basic Information
CAS Number
1513857-77-6
Molecular Formula
C24H27F2N5O4
Molecular Weight
487.51 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- Pemigatinib
- INCB054828
- Y6BX7BL23K
- 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-4,7-dihydropyrrolo[4,5]pyrido[1,2-d]pyrimidin-2-one
- 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-[(morpholin-4-yl)methyl]-1,3,4,7-tetrahydro-2Hpyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
- Pemazyre
- Pemazyre (TN)
- Pemigatinib [INN]
- Pemigatinib [USAN]
- Pemigatinib [USAN:INN]
- Fgfr inhibitor INCB054828
- Pemigatinib (JAN/USAN/INN)
- GTPL9767
- Pemig
MDL Number
MFCD31706227
FAQ
What are the physical and chemical properties of 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(4-morpholinylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one (CAS: 1513857-77-6)?
This compound is a crystalline solid with a molecular weight of approximately 461.27 g/mol. It has limited water solubility and high solubility in polar organic solvents like DMSO. Chemically, it is reactive towards nucleophiles and exhibits good stability under basic conditions but is susceptible to hydrolysis under acidic conditions. It is an important intermediate in the synthesis of various pharmaceuticals.
How is 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(4-morpholinylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one (CAS: 1513857-77-6) typically synthesized?
This compound is synthesized via a multi-step process involving the coupling of 2,6-difluoro-3,5-dimethoxybenzaldehyde and morpholine, followed by a condensation reaction using ethyl chloroformate. The synthesis yields a product with good purity, and the reaction is typically carried out under mild conditions to ensure high selectivity and yield.
What industries use 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(4-morpholinylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one (CAS: 1513857-77-6)?
This compound is primarily used in the pharmaceutical industry as a key intermediate in the synthesis of novel drugs. It may also find applications in the development of sensors and semiconductors, although its specific uses in these areas are limited.
What precautions should be taken when handling 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(4-morpholinylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one (CAS: 1513857-77-6)?
When handling this compound, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.
Related Compounds
![N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N~5~-{[(2-methyl-2-propanyl)oxy]carbonyl}ornithine structure](https://static.chemtradehub.com/structs/118/118476-89-4-a153.webp "N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N~5~-{[(2-methyl-2-propanyl)oxy]carbonyl}ornithine structure")
N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N~5~-{[(2-methyl-2-propanyl)oxy]carbonyl}ornithine
CAS Number:
118476-89-4
Molecular Formula:
C25H30N2O6
3-(2-Chlorophenyl)-6-(2,6-difluorophenyl)-1,2,4,5-tetrazine
CAS Number:
162320-67-4
Molecular Formula:
C14H7ClF2N4
![Zirconium(4+) tetrakis[ethyl(methyl)azanide] structure](https://static.chemtradehub.com/structs/175/175923-04-3-d680.webp "Zirconium(4+) tetrakis[ethyl(methyl)azanide] structure")
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