Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Basic Information

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CAS Number

140171-66-0

Molecular Formula

C19H23ClN2O5

Molecular Weight

394.86 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Density

1.247±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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CC1=C(C(C(=C(N1)COCCN)C(=O)OC)C2=CC=CC=C2Cl)C(=O)OC

InChI

InChI=1S/C19H23ClN2O5/c1-11-15(18(23)25-2)16(12-6-4-5-7-13(12)20)17(19(24)26-3)14(22-11)10-27-9-8-21/h4-7,16,22H,8-10,21H2,1-3H3

InChIKey

UDSAEMGNQXMCDF-UHFFFAOYSA-N

LogP

1.8762

Topological Polar Surface Area

99.88000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

632

Synonyms & References

English

Amlodipine Dimethyl Ester
Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
dimethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
EPZ 5676
dimethylamlodipine
UNII-5TQ5PD1804
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid 3,5-dimethyl Ester
Amlodipine besilate impurity F
Amlodipine EP Impurity F
AMLODIPINE BESILATE IMPURITY F [EP IMPURITY]
Q27262859
140171-66-0
Dimethyl (4RS)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
UDSAEMGNQXMCDF-UHFFFAOYSA-N
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, dimethyl ester
5TQ5PD1804
F19443
SCHEMBL5477290
2-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester
AKOS027422467
AS-78726
J-007364
Dimethyl (4RS)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Amlodipine Besilate Imp. F (EP); Amlodipine Imp. F (EP); Dimethyl (4RS)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; Amlodipine Related Compound F; Amlodipine Besilate Impurity F; Amlodipine Impurity F
2-(2-amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester
Dimethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Dimethyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Amlodipine besilate impurity F [EP]
3,5-Dimethyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
(+/-)-3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, dimethyl ester
DTXSID301111409

MDL Number

MFCD19704867

FAQ

What are the physical and chemical properties of Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-66-0)?

Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate is a crystalline compound with a molecular weight of approximately 483.91 g/mol. It has a high solubility in organic solvents like DMSO and moderate solubility in water. This compound is relatively stable but reacts with strong bases to form the corresponding sodium salt. It is not flammable but should be handled under standard laboratory conditions.

How is Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-66-0) typically synthesized?

Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate is synthesized via a multi-step process involving the synthesis of key intermediates. The synthesis typically requires the use of chloroanilines, amines, and carboxylic acids. The process often involves protection and deprotection steps, and the use of appropriate solvents and catalysts. The yield is around 80-85%, and the purity is over 95% after purification.

What industries use Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-66-0)?

Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate is primarily used in the pharmaceutical industry for the development of novel drugs. It also finds applications in the polymer industry as a functional monomer and in the sensor industry for its reactivity and selectivity. Additionally, it has potential in the semiconductor industry due to its electronic properties.

What precautions should be taken when handling Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-66-0)?

When handling Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents. This compound should be stored in a cool, dry place away from direct sunlight and flammable materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information.