diethyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate

Basic Information

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CAS Number

140171-65-9

Molecular Formula

C21H27ClN2O5

Molecular Weight

422.91 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.209±0.06 g/cm3 (20 ºC 760 Torr),

Solubility

Insuluble (9.3E-3 g/L) (25 ºC),

SMILES

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CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OCC)COCCN)C

InChI

InChI=1S/C21H27ClN2O5/c1-4-28-20(25)17-13(3)24-16(12-27-11-10-23)19(21(26)29-5-2)18(17)14-8-6-7-9-15(14)22/h6-9,18,24H,4-5,10-12,23H2,1-3H3

InChIKey

BGGLOZPVAWMSEB-UHFFFAOYSA-N

LogP

2.6564000000000005

Topological Polar Surface Area

99.88000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

662

Synonyms & References

English

Amlodipine Diethyl Ester
Diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
diethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
UNII-T71NAR24SN
Amlodipine besilate impurity E
SCHEMBL5324225
AS-78323
140171-65-9
diethyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate
Amlodipine EP Impurity E
Diethyl (4RS)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(+/-)-3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3,5-diethyl ester
T71NAR24SN
3-Ethyl 5-Ethyl 4-(2-Chlorophenyl)-6-methyl-2-[[2- [(2-aminoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate
AMLODIPINE BESILATE IMPURITY E [EP IMPURITY]
Diethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, diethyl ester
J-007363
Amlodipine besilate impurity E [EP]
Diethyl (4RS)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
A899193
AKOS027422466
F19444
Diethyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Q27289753
CS-0337385
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3,5-diethyl ester

MDL Number

MFCD19704866

FAQ

What regulatory guidelines apply to diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-65-9)?

Diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-65-9) is subject to regulation under the Globally Harmonized System (GHS) for Classification and Labeling of Chemicals, REACH in the European Union, and the FDA for pharmaceutical applications. Specific requirements include hazard communication, environmental protection, and safe handling practices.

Are there alternatives to diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-65-9) in synthesis?

Alternative reagents for synthesizing similar compounds include 2-aminophenol derivatives and other diarylpyridine compounds. Isomers such as 1,4-dihydropyridine-3,5-dicarboxylic acid derivatives can also be used as substitutes. However, the choice depends on the specific chemical properties and desired end-product.

What is the market or research trend for diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-65-9)?

The market for diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-65-9) is driven by its application in pharmaceuticals and research. Recent trends indicate increased interest in its use for treating cardiovascular diseases. Research is also focusing on its potential in drug delivery systems and as a precursor for other medicinal compounds.

How should waste containing diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-65-9) be handled?

Waste containing diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS: 140171-65-9) should be collected in appropriate containers and stored in a well-ventilated area. For disposal, professional waste disposal services are recommended to ensure compliance with environmental regulations. Incineration may be considered, but it should be conducted in an enclosed system to minimize emissions.