4-(2,2,2-Trifluoroethoxy)phenol

Basic Information

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CAS Number

129560-99-2

Molecular Formula

C8H7F3O2

Molecular Weight

192.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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C1=CC(=CC=C1O)OCC(F)(F)F

InChI

InChI=1S/C8H7F3O2/c9-8(10,11)5-13-7-3-1-6(12)2-4-7/h1-4,12H,5H2

InChIKey

CWLQMEMHOVBEGW-UHFFFAOYSA-N

LogP

2.3333000000000004

Topological Polar Surface Area

29.46 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

150

Synonyms & References

English

SCHEMBL3271257
EN300-55750
AKOS008122323
MFCD04972983
A1-10102
129560-99-2
D92865
4-(2,2,2-trifluoroethoxy)phenol
DTXSID60517689
FT-0692290
AS-76896
Z381414680
Phenol, 4-(2,2,2-trifluoroethoxy)-
4-(2,2,2-Trifluoroethoxy)phenol
Phenol,4-(2,2,2-trifluoroethoxy)-
4-((trifluoro)ethoxy)phenol
4-trifluoroethoxyphenol
AC1Q78XU
ACMC-1CGAD
AGN-PC-00KTHP
CTK4B6318
SBB091381
SureCN3271257

MDL Number

MFCD04972983

Customs Code

2909500000

FAQ

What are the physical and chemical properties of 4-(2,2,2-Trifluoroethoxy)phenol (CAS: 129560-99-2)?

4-(2,2,2-Trifluoroethoxy)phenol is a colorless to white solid with a molecular weight of approximately 218.15 g/mol. It is only slightly soluble in water but more soluble in polar organic solvents. The compound is reactive towards bases and can undergo substitution reactions. It is stable under normal conditions but should be stored away from strong oxidizers and reducing agents.

How is 4-(2,2,2-Trifluoroethoxy)phenol (CAS: 129560-99-2) typically synthesized?

4-(2,2,2-Trifluoroethoxy)phenol is typically synthesized via the reaction of 4-hydroxyphenol with trifluoroethanol in the presence of a Lewis acid catalyst such as aluminum trichloride. The reaction involves the substitution of the hydroxyl group with the trifluoroethoxy group, yielding a high yield of the desired product.

What industries use 4-(2,2,2-Trifluoroethoxy)phenol (CAS: 129560-99-2)?

4-(2,2,2-Trifluoroethoxy)phenol is used in various industries, particularly in the pharmaceutical sector for the synthesis of drug intermediates, in the polymer industry for the production of advanced polymers, and in the sensor industry for the development of chemical sensors. It is also used in the semiconductor industry for manufacturing processes.

What precautions should be taken when handling 4-(2,2,2-Trifluoroethoxy)phenol (CAS: 129560-99-2)?

When handling 4-(2,2,2-Trifluoroethoxy)phenol, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or a fume hood. In case of a spill, it should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling instructions.