Paromomycin Sulfate

Basic Information

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CAS Number

1263-89-4

Molecular Formula

C23H43N3O11

Molecular Weight

713.71 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

>360°C

Boiling Point

1059.2°C at 760 mmHg

Water Solubility

Soluble in water

Flash Point

522.2 °C

Solubility

H2O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.

Specific Rotation

+51° (c=5, water)

SMILES

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C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

InChI

InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChIKey

LJRDOKAZOAKLDU-UDXJMMFXSA-N

LogP

-9.514500000000016

Topological Polar Surface Area

421.92 Å²

Hydrogen Bond Donor/Acceptor

20 / 23

Complexity

952

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Toxicity

LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)

Synonyms & References

English

DTXSID5047829
Paromomycin sulfate, Antibiotic for Culture Media Use Only
D-STREPTAMINE, O-2-AMINO-2-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4)-O-(O-2,6-DIAMINO-2,6-DIDEOXY-.BETA.-L-IDOPYRANOSYL-(1->3)-.BETA.-D-RIBOFURANOSYL-(1->5))-2-DEOXY-, SULPHATE (SALT)
CCG-270398
SMR000058551
Paromomycin sulfate (JAN/USP)
Humycin sulfate
Gabbroral
PAROMOMYCIN SULFATE [USP-RS]
EINECS 230-575-5
(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; sulfuric acid
D00868
Aminosidine sulfate;Paromomycin sulfate salt
PAROMOMYCIN SULFATE [WHO-DD]
PAROMOMYCIN SULFATE [MART.]
PENICILLAMINE [WHO-IP]
Paromomycin, sulfate (1:1)
NS00076342
EINECS 215-031-7
Gabbromicina
ESTOMYCIN SULFATE
PAROMOMYCIN SULFATE [USP MONOGRAPH]
845NU6GJPS
Humatin (TN)
PAROMOMYCIN SULFATE (USP MONOGRAPH)
O-2,6-DIAMINO-2,6-DIDEOXY-beta-L-IDOPYRANOSYL-(1->3)-O-beta-D-RIBOFURANOSYL-(1->5)-O-(2-AMINO-2-DEOXY-alpha-D-GLUCOPYRANOSYL-(1->4))-2-DEOXYSTREPTAMINE SULPHATE (SALT)
Aminosidin sulfate
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate
D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-1-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate (1:1) (salt)
O-2,6-DIAMINO-2,6-DIDEOXY-.BETA.-L-IDOPYRANOSYL-(1->3)-O-.BETA.-D-RIBOFURANOSYL-(1->5)-O-(2-AMINO-2-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4))-2-DEOXYSTREPTAMINE SULPHATE (SALT)
D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-, Sulfate(salt)

MDL Number

MFCD00079278

FAQ

What is Paromomycin Sulfate (CAS: 1263-89-4)?

Paromomycin Sulfate (CAS: 1263-89-4) is an aminoglycoside antibiotic used primarily for treating parasitic infections. Its chemical formula is C22H45NO12·H2SO4, and it appears as a white crystalline powder. It is highly soluble in water, with a molecular weight of 572.7 g/mol. This compound is known for its broad-spectrum antiprotozoal activity, making it a key component in pharmaceutical formulations.

What are the main uses of Paromomycin Sulfate (CAS: 1263-89-4)?

Paromomycin Sulfate (CAS: 1263-89-4) is mainly used in pharmaceuticals to treat leishmaniasis, a parasitic disease caused by Leishmania species. It also serves as an antiprotozoal agent for infections like trypanosomiasis and schistosomiasis. In research, it is utilized to study antibiotic mechanisms. Its applications are critical in both medical and industrial contexts, particularly in combating tropical diseases.

Is Paromomycin Sulfate (CAS: 1263-89-4) safe?

Paromomycin Sulfate (CAS: 1263-89-4) is generally safe when used as directed, but it may cause side effects such as nephrotoxicity or ototoxicity. Proper handling, including gloves and ventilation, is recommended to minimize risks. It adheres to safety standards set by regulatory agencies like the FDA. Always follow guidelines for safe use and storage to ensure effectiveness and reduce potential harm.

How should Paromomycin Sulfate (CAS: 1263-89-4) be stored?

Paromomycin Sulfate (CAS: 1263-89-4) should be stored in a cool, dry place, away from light, at 2-8°C. Keep it in airtight, dark-colored containers to maintain stability and prevent degradation. Avoid exposure to moisture and extreme temperatures. Proper storage is essential to preserve its potency and ensure safety during handling and use.