How is (2R)-3-Methoxy-2-butanamine hydrochloride (CAS: 1807938-53-9) typically synthesized?

(2R)-3-Methoxy-2-butanamine hydrochloride is typically synthesized by the reaction of 2-butanamine with methanol followed by protonation with concentrated hydrochloric acid. The reaction is conducted in a solvent such as ethanol at room temperature, and the product is isolated by filtration and recrystallization from an appropriate solvent. The yield is generally good, and the reaction is stereoselective, producing the (2R) enantiomer with high purity.