Compound Q&A
How is 5-(4-bromophenyl)-4-methyl-4H-1,2,4-triazole-3-thiol (CAS: 494194-50-2) typically synthesized?
Answer
5-(4-bromophenyl)-4-methyl-4H-1,2,4-triazole-3-thiol is typically synthesized via the reaction of 4-bromobenzoyl isothiocyanate with methyl 4-methyl-1,2,4-triazole-3-carboxylate in the presence of a base such as potassium carbonate. The reaction is carried out in a suitable solvent like dimethylformamide (DMF) at room temperature. The yield is around 70-80%, and the product is isolated by column chromatography.
About
CAS No
494194-50-2
English Name
5-(4-bromophenyl)-4-methyl-4H-1,2,4-triazole-3-thiol
Molecular Formula
C9H8BrN3S
Molecular Weight
270.16 g/mol
SMILES
CN1C(=NNC1=S)C2=CC=C(C=C2)Br
InChIKey
FHXAECCDIGEICD-UHFFFAOYSA-N
Last Updated: 2026-04-01 14:15
