Compound Q&A
How is 2-{(3S)-7-Fluoro-4-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}-N-methylacetamide (CAS: 1850385-64-6) typically synthesized?
Answer
![2-{(3S)-7-Fluoro-4-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}-N-methylacetamide](https://static.chemtradehub.com/structs/185/1850385-64-6-7d3e.webp "2-{(3S)-7-Fluoro-4-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}-N-methylacetamide")
This compound is synthesized through a multistep process involving the condensation of a fluoro-3,4-dihydro-2H-1,4-benzoxazine with N-methylacetamide, followed by a cyclocondensation reaction. The synthesis requires careful control of pH and temperature to achieve high yields and selectivity. Commonly used solvents include acetonitrile and water. Catalytic amounts of acid or base may be used to facilitate the reactions.
About
CAS No
1850385-64-6
English Name
2-{(3S)-7-Fluoro-4-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}-N-methylacetamide
Molecular Formula
C20H18FN3O5
Molecular Weight
399.38 g/mol
SMILES
CNC(=O)C[C@H]1COC2C=C(F)C=CC=2N1C(=O)C1=CC2NC(=O)COC=2C=C1
InChIKey
MBKYLPOPYYLTNW-ZDUSSCGKSA-N
Last Updated: 2026-04-01 08:55
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