Compound Q&A
How is 3-hydroxy-3-[2-(2-naphthyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one (CAS: 6765-52-2) typically synthesized?
Answer
![3-hydroxy-3-[2-(2-naphthyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one](https://static.chemtradehub.com/structs/676/6765-52-2-dc29.webp "3-hydroxy-3-[2-(2-naphthyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one")
3-Hydroxy-3-[2-(2-naphthyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one (CAS: 6765-52-2) can be synthesized via a multi-step process involving the condensation of 2-naphthylacetic acid with indole-3-carbaldehyde, followed by hydroxylation and acetylation steps. The process typically requires strong acids like sulfuric acid and heat. The overall yield is moderate, around 50-60%, and requires high selectivity for key steps.
About
CAS No
6765-52-2
English Name
3-hydroxy-3-[2-(2-naphthyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one
Molecular Formula
C20H15NO3
Molecular Weight
317.34 g/mol
SMILES
C1=CC=C2C=C(C=CC2=C1)C(=O)CC3(C4=CC=CC=C4NC3=O)O
InChIKey
IVAVELBVHXCUDH-UHFFFAOYSA-N
Last Updated: 2026-03-29 08:05
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