How is N,N'-1,2-Ethanediylbis(2-iodoacetamide) (CAS: 7250-43-3) typically synthesized?

N,N'-1,2-Ethanediylbis(2-iodoacetamide) is typically synthesized via the reaction of ethanediamine with iodine and acetic anhydride. The reaction involves the iodination of the acetyl groups followed by acetylation of the amino groups. This method provides good yield and selectivity, although appropriate catalysts such as pyridine are often used to optimize the process.